Search results for "LIVER TARGETING"

showing 6 items of 6 documents

Glycosylated macromolecular conjugates of antiviral drugs with a polyaspartamide.

2004

Two new polymeric conjugates for specific liver targeting were prepared by conjugation of sugar moieties and antiviral drugs to alpha, beta-poly[N-2-(hydroxyethyl)-DL-aspartamide] (PHEA). PHEA-galactopyranosylphenylthiocarbamide-mono-O-succinylganciclovir (conjugate 7) and PHEA-mannopyranosylphenylthiocarbamide-O-succinylacyclovir (conjugate 8) were synthesized according to a multi-step procedure which allowed for obtaining high product yield and process standardization. Conjugate 7 contained 7.5 and 8.5% of galactose and ganciclovir (substituent/repeating unit, mol/mol), respectively, and conjugate 8 contained 14.2 and 10.8% of mannose and acyclovir, respectively. In vitro studies demonstr…

Ganciclovirchemistry.chemical_classificationMaleMice Inbred BALB CGlycosylationStereochemistryMacromolecular SubstancesSubstituentPharmaceutical ScienceMannoseGlycosidic bondAntiviral Agentschemistry.chemical_compoundHydrolysisMicePoly(hydroxyethylaspartamide) Bioconjugates Polymer therapeutics Liver targeting AntiviralschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoGalactosemedicineMoietyAnimalsPeptidesmedicine.drugConjugateJournal of drug targeting
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Nanodevices based on a novel galactosaminated phospholipid-polyaspartamide for liver targeting of a ribavirin prodrug

2011

LIVER TARGETING GRAFT COPOLYMERS POLIASPARTAMIDESettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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GALACTOSE-FUNCTIONALISED POLYMERIC MICELLES AS HEPATOCYTE-TARGETED CARRIERS

2012

RIBAVIRIN TRIPALMITATELIVER TARGETINGPOLYMERIC MICELLES
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GALACTOSE-DECORATED POLYMERIC CARRIERS FOR HEPATOCYTE-SELECTIVE DRUG TARGETING

2015

In this paper, the current available strategies to realize galactose-decorated nanostructured polymeric systems are summarized. These carriers are designed in order to obtain targeted drug delivery to hepatocytes via galactose (GAL) moieties, i.e., for the treatment of viral hepatitis or liver cancer that are the greater causes of global disability and mortality. Usually, the main followed strategy to obtain galactosylated polymeric carriers is to use galactosylated copolymers. The chemical modifications of preformed polymers with sugar-containing reagents is followed for obtaining lactosaminated human albumin, galactosylated phospholipid-polyaminoacid and polylactide (PLA)- polyaminoacid c…

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoAsialoglycoprotein receptor (ASGP-R) carboxymethyl chitosan (CMC) galactose (GAL) hepatocytes lactosaminated albumin liver targeting poly(ε-caprolactone) (PCL) polyamidoamine (PAMAM) dendrimers polycarbonates polylactide (PLA) xyloglucan αβ-poly(N-2-hydroxyethyl)-DLaspartamide (PHEA).
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PREPARATION AND CHARACTERIZATION OF GALACTOSILATED NANODEVICES CONTAINING A RIBAVIRIN PRODRUG FOR LIVER TARGETING.

2012

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoNANOPARTICLESRIBAVIRIN PRODRUGLIVER TARGETING
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Novel galactosylated nanoparticles containing a ribavirin prodrug as hepatic cell-targeted carriers for hcv treatment

2012

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoRIBAVIRIN PRODRUGLIVER TARGETINGPOLYMERIC NANOPARTICLES
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